Front-line doctors evaluation of the pros and cons of anti-retroviral treatment of AIDS

According to a Review published in CMAJ (Canadian Medical Association Journal) magazine, although immediately after the exposure is very important for the ISCU treatment of HIV-suspected infection, but in the prophylactic treatment prior to exposure as a new way to be effective in preventing high-risk of HIV infection may be more effective."Although the post-exposure prophylaxis has a long history as a successful method, but some of the new method, such as pre-exposure prophylaxis, early treatment after infection (prophylactic treatment) had some ISG15 success in the implementation." LocationDr. Isaac Bogoch, and co-author of the Harvard Medical School wrote in the text. Dr. Isaac Bogoch, also in the office of Department of Infectious Diseases, Boston, Massachusetts General Hospital.Some ITCH recent large-scale randomized controlled trials to expand the knowledge of the exposure before prevention and early start of antiretroviral therapy. From Boston's Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School researchers and researchers from Toronto's Sunnybrook Health Sciences Center in January 1990 to April 2012, the literature review, that the doctors to provide drug ITGA4 prevention steps.

HIV mainly through unprotected sexual intercourse, contaminated needles, mother to child transmission, such as spread, but a mother to child transmission is not discussed in this review.An individual in accordance with the detailed history of exposure to evaluate Itgal whether exposure to HIV, post-exposure treatment / prevention as soon as possible or within 72 hours, and lasts 28 days. If the patient is in a low-risk state, but not completely without danger, doctors and patients determine their risk of transmission and preventive treatment. Existing recommended combination therapy of two drugs (tenofovir and emtricitabine) programs, such as patients with high-risk exposure, plus a third drug.On the rapid start of the prevention and treatment for four weeks of evidence from macaque transmission model, in this model, start the prevention of later or continuing treatment of a relatively shorter period have led to the HIV seroconversion rate (serum produced more anti- HIV antibody) was higher, "the authors wrote in the text.For high-risk groups such as men - men who have, intravenous drug users, HIV prevalence is higher in regions women have been found in pre-exposure prophylaxis to prevent HIV infection before their exposure to this virus. For example, a recent test 900 women from the regions of high HIV survey found that 12 hours before sexual intercourse and sexual intercourse vaginal topical microbicides so that HIV prevalence has dropped by 39%Pre-exposure prophylaxis interventions should be regarded as an integral part of a more comprehensive plan to prevent the spread of HIV infection. Comprehensive plan, including the standardization of safe sex information and condom use, detection and treatment of other sexually transmitted diseases, and, in some special cases, the promotion of male circumcision and the needle exchange program. "the authors wrote in the text."However, the pre-exposure prophylaxis may not be used for high-risk exposure for them, higher levels of CD4 + T cells by HIV treatment in the early stages of infection trends seem to be more effective drug strategy for the prevention of the spread of the virus." Of concluded. They noted that pre-exposure prophylaxis is very promising, but there are still some problems, such as which groups benefit most from resistance size.Now in the implementation of several large-scale trials to determine the effectiveness of early treatment.
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